ALK-positive anaplastic large-cell lymphoma with marked leukemoid reaction and hemophagocytic lymphohistiocytosis

ALK- negative Anaplastic Large Cell Lymphoma of Bone

MicroRNA and ALK-positive anaplastic large cell lymphoma.

In this review we describe the current literature covering the role of microRNA in anaplastic large cell lymphoma (ALCL). MicroRNA is one of the best characterized subgroups of non-coding RNAs and it is now becoming clear that its importance in oncogenesis has been greatly underestimated. In ALCL the deregulation of a diverse range of microRNA has been demonstrated however much less is known ab...

Leukemic phase of ALK-positive anaplastic large cell lymphoma.

A 25-year-old woman presented with lymphadenopathy. Peripheral blood showed leukocytosis, anemia, and thrombocytopenia (white blood cell count, 102.9 3 10/L; hemoglobin level, 76 g/L; and platelet count, 32 3 10/L). Peripheral smear demonstrated a predominant population of large cells with reticular chromatin, folded to irregular nuclear contours, and abundant basophilic cytoplasm. Many cells c...

Endobronchial ALK-Positive Anaplastic Large Cell Lymphoma Presenting Massive Hemoptysis

Primary anaplastic large cell lymphoma (ALCL) of the lung is highly aggressive and quite rare. We report here a case of anaplastic lymphoma kinase-positive endobronchial ALCL, that was initially thought to be primary lung cancer. A 68-year-old woman presented with hemoptysis, dyspnea, and upper respiratory symptoms persisting since 1 month. The hemoptysis and and bronchial obstruction lead to r...

ALK-positive anaplastic large cell lymphoma: an evolving story.

The current classification of lymphoid neoplasms is based on the integrated utilisation of morphological, immunohistochemical, genetic and clinical criteria to define disease entities. Anaplastic large cell lymphoma is a paradigm for the identification of a disease entity based on morphological observations and immunophenotype, which paved the way for the subsequent discovery of the characteris...